The very best thing it is to position yourself so your audience can readily see you without anything blocking your body from them.

Lecterns actually create a barrier between you and your audience and should be avoided if possible.

Remember, if you are standing, the entire room is available for you to move around in as you talk. I recommend you do not go any deeper than one third of the audience so you maintain maximum eye contact.

For more presentation skills tips take a peek at www.impressionmanagement.com.